اخبار القسم en
Head of the Department of Applied Sciences supervising a PhD student in the field of Laser Science and Technology.
Written by ali
Professor Raid Abdul Wahab Ismail, Head of the Department of Applied Sciences, supervised a postgraduate student in the field of Laser Science and Technology
The doctoral thesis of the postgraduate student, Safaa Abdul Salam Abdul Rahman, was discussed.
Her thesis, titled: :
"Preparation of a Thin Nanostructured Cerium Oxide Film by Pulsed Laser Deposition on Silicon for Electro-Optical Applications"
The discussion was held in the hall named after the late Professor Dr. Abdul-Muttalib Ibrahim Al-Sheikh in the department building.
The examination committee consisted of
- Professor Alwan Mohammed Alwan Department of Applied Sciences / Laser Science and Technology Branch - Chairman
- Professor Wafa Khalid Khalaf Department of Applied Sciences / Applied Sciences Research Unit - Member
- Assistant Professor Alaa Abdul Jabbar Hussein Department of Applied Sciences / Laser Science and Technology Branch - Member
- Professor Hassan Abdul Sahib Hadi Al-Mustansiriya University / College of Education / Department of Physics - Member
- Professor Haider Abdul Redha Saleh Department of Applied Sciences / Laser Science and Technology Branch - Member
- Assistant Professor Suad Salem Shakir Department of Applied Sciences / Applied Physics Branch - Member
- Professor Muslim Fadel Jawad Department of Applied Sciences / Laser Science and Technology Branch - Member and Supervisor
- Professor Raid Abdul Wahab Ismail Department of Applied Sciences / Laser Science and Technology Branch - Member and Supervisor
Cerium oxide (CeO2) is an attractive semiconducting material that draws attention in optoelectronics and photovoltaics applications. Due to the remarkable progress in photovoltaic technology, enhancing efficiency and minimized the costs have emerged as global challenges for the solar industry. A crucial aspect of this advancement involves the creation of solar cell antireflection coating, which play a significant role in minimizing sunlight reflection on the cell surface. The most crucial issue was the preparation method of Cerium oxide (CeO2) nanostructure films with control of Preparation conditions for the desired application. CeO2 nanostructure films fabricated by pulsed laser deposition (PLD), home-made pulsed laser deposition system used in this work consisted of a Q-switched Nd:YAG laser system and a vacuum chamber. The Nd:YAG laser used to deposit the CeO2 film emitted a laser beam with a wavelength (λ) of 1064 nm, 7 nanoseconds pulse duration, and 6 Hertz (PRF) a pulse repetition frequency. The laser beam was focused by a 7-cm conversion lens, and the laser fluence was changed from 63.66 to 101.86 J/cm2 and number of pulses used for film deposition of CeO2 film was changed from 900 to 1200 pulses. This thesis is based on three parts, the first part is the preparation of films under different preparation conditions and their use as anti-reflection coatings that contribute to increasing the efficiency of solar cells. The second part is the use of cerium oxide films prepared under different conditions in terms of laser energy and number of pulses in preparing photodetectors. As for the last part, fabricate high-efficiency CeO2/Si photodetector and study effect of (RTA) rapid thermal annealing on the performance of CeO2/Si photodetector. In the first section, CeO2 thin films have been used as anti-reflection coating (ARC) for Si solar cells. X-ray diffraction measurements showed grown films were crystalline with cubic and hexagonal phases with a preferred orientation along the (111) plane. The degree of crystallinity of the film increases with the increase in the laser fluence. while all peaks can be indexed to a face-centered cubic (fcc) phase of CeO2 fluorite structure for films prepared at different number of laser pulses. Scanning electron microscope (FE-SEM) results reveal that the film’s morphology and film uniformity improved as the laser fluence increases, the film deposited at 63.66 J/cm2 exhibits a surface morphology characterized by densely packed particles with spherical shapes on the film’s surface. The average grain size of the film prepared at 900 pulses was found to be 22 nm, and it increases to 44.7 nm as the number of laser pulses increases to 1200 pulses. Also, nanostructured CeO2 films on a glass substrate exhibit quite uniform, crack-free, and dense. Also, film thickness was measured by (FE-SEM Cross Section). Raman shift of the CeO2 film as a function of laser energy density and number of laser pulses were investigated. The observed peaks at 463 cm−1 can be attributed to CeO2. The room temperature photoluminescence (PL) spectra of CeO2 films deposited on Si substrate with an excitation source of (325 nm) as wavelength showed a wide range of emission, spanning from 350 to 500 nm. This broadband emission is likely attributed to crystal defects, such as oxygen vacancies, which possess electronic energy levels below the 4f band. Photovoltaic properties illustrated that the conversion efficiency of the silicon solar cell increases from 8.37 to 14.04% after deposited with ARC CeO2 film at laser energy density of 76.39 J/cm2. The maximum PCE was 19.27% and fill factor of 87% was obtained after the deposition of silicon solar cell with cerium oxide nanostructured film deposited at 1000 laser pulses. The CeO2 films deposited at 76.39 J/cm2 laser pulse energy density have highest hydrophobicity with the largest water contact angle (WCA) of 117.98°, while at 1000 pulse CeO2 films exhibited highest hydrophobicity with the largest water contact angle (WCA) of 111.90°. In the second section, CeO2 films were deposited on silicon substrates with different laser power densities and different number of laser pulses to fabricate high-performance CeO2/Si photodetectors. Hall effect results confirmed that the Hall coefficient of all films is negative, indicating that the CeO2 film is n-type. Field emission scanning electron microscopy (FE-SEM) results illustrated that the CeO2 film has a spherical grain morphology with an average grain size ranging from 33 to 54 nm, depending on the laser energy density. The film deposited at various numbers of laser pulses also has spherical grains with an average grain size ranging from 32 to 44 nm, depending on the number of pulses. The optical properties of the CeO2 film showed that the optical energy gap of the films decreased from 3.5 to 3 eV as the laser energy density increased from 63.66 to 101.86 J/cm2, and changed from 3.4 to 3 when number of pulses changed from 900-1000 pulse. The I-V characteristics of CeO2/p-Si heterojunctions showed clear rectification characteristics. The CeO2/Si photodetector fabricated at 63.66 J/cm2 showed the highest responsivity of 0.69 A/W at 450 nm, detectivity as high as 1.5 × 1010 Jones at 450 nm, and an external quantum efficiency of 92% when biased to 5 V. Also, photodetector fabricated at 1100 pulse exhibited maximum value of responsivity at wavelength 450 nm and was 0.49 A/W, D* of 1×1010 Jones at 500 nm, and EQE of 61% at 450 nm. The last section of this thesis covers the deposition of cerium oxide films on CeO2/Si silicon substrates prepared by pulsed laser deposition technique at a laser energy density of 63.66 J/cm2 and then studying the effect of rapid thermal annealing (RTA) on the photodetector at different times (2, 4, 6, 8 min) and comparing them with CeO2/Si without annealing. The (I-V) characteristics of the CeO2/p-Si photodetector show good rectification properties after annealing compared to without annealing. The highest responsivity of the photodetector was (0.6 A/W) at an annealing time of 6 min compared to the photodetector without annealing (A/W 0.4), and a detectivity of (3.8×1010) at an annealing time of 6 min while the detectivity of the photodetector without annealing was (3×1010). The maximum photocurrent of the junction was observed when the annealing time was 6 min. The rise and fall times of the photodetector fabricated at 6 min were 0.3 and 0.32 s, indicating that this photodetector has good junction characteristics. The obtained results of this work confirm that the properties of cerium oxide films are suitable for optoelectronic applications.
A postgraduate student in the field of medical and industrial materials science earns a master's degree for her work on "Development and Improvement of the Properties of Electrical Insulators Made from Local Raw Materials."
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The Department of Medical and Industrial Materials Science awarded a master’s degree to postgraduate student "Hajar Maher Abdullah."
The Department of Medical and Industrial Materials Science awarded a master’s degree to postgraduate student "Hajar Maher Abdullah" for her thesis titled:
“Developing and improving the properties of electrical insulators manufactured from local raw materials“
The defense was held in the hall named after the late Professor Dr. Abdul Muttalib Ibrahim Al-Sheikh in the department building. The examination committee consisted of
- Professor Dr. Inas Mohi Hadi
- Department of Applied Sciences, Medical and Industrial Materials Branch - Chair
- Assistant Professor Dr. Ban Mazen Mazahem
- University of Baghdad, College of Science, Department of Physics - Member
- Assistant Professor Dr. Mufeed Abdul Latif Jaleel
- Department of Applied Sciences, Medical and Industrial Materials Branch - Member
- Assistant Professor Dr. Mujahed Mohammed Najm
- Department of Applied Sciences, Medical and Industrial Materials Branch - Member and Supervisor
- Assistant Professor Dr. Ban Ayoub Youssef
- Department of Applied Sciences, Applied Physics Branch - Member and Co-Supervisor
Local raw materials were used: (Duekhla Kaolinitic claystone) urdhuma silica sand and flint clay and karst Bauxite and porcelains. Another local material were used addition (Pure Silica, Silica from rice husk ash, MgCo3, Mg (OH)2. The raw materials have been crushed and grinded to sizes smaller than 45µ except the silica sand and kaolin that have been grinded to different sizes 20 and 45 µ. mixtures of different proportions were prepared from the above-mentioned materials. disks samples were formed by semi-dry pressing using the pressing force of 1000kg/cm2 The samples were dryers add fired in 1300,1350,1400 and 1450°C according firing program 50°C /hour in socking time 2 hours. Physical, mechanical, electrical and mineral evaluated tests were done to the samples. Samples fired at 1400°C give the best ratings. Apparent porosity and water absorption ratings were very low. Bulk density, compressive strength, breakdown strength, and dielectric constant ratings were high. The samples that were fired at a temperature of 1450°C did not have good physical, mechanical and electrical specifications because the samples containing 50%, 60% and 70% cordierite were molten, which led to their deformation.
The head of the Applied Sciences Department is following up the final work on the emergency staircase in the laboratories and classrooms building
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The head of the Applied Sciences Department is following up the final work on the emergency staircase in the laboratories and classrooms building
Professor Dr. Raid Abdul Wahab Ismail, Head of the Applied Sciences Department, personally followed up the final stages of the construction of an emergency staircase for the laboratories and classrooms building.
During the visit, the Head of the Department reviewed all details and plans related to the exit points on each floor. He emphasized that these exits should be located in places that allow our students, faculty members, and staff to easily and smoothly evacuate in the event of any emergency, God forbid.
Accompanying him on this tour of the student building floors was the department's assistant for administrative affairs, Professor Dr. Oday Mohsen Naif, to oversee the progress of the work and ensure the implementation of the Head of the Department's directives and observations
Applied Chemistry held a workshop on filling the annual assessment form
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Applied Chemistry held a workshop on filling the annual assessment form
As part of the distinguished scientific activities organized by the Department of Applied Chemistry, a workshop was held in the late Professor Abdul Mutalib Ibrahim Sheikh Hall in the department building. The workshop focused on how to fill out the annual evaluation form, under the direct supervision of the Head of the Applied Chemistry Department, Prof. Khalida Farhan Suhail, with follow-up from the department coordinator, Dr. Thamer Adnan Abdullah. The workshop was led by the Director of the Quality and University Performance Division, Prof. Duha Saadi Ahmed, alongside the instructor in the Applied Chemistry Department, Assoc. Prof. Dhafar Saber Khalaf. A select group of faculty members and department staff attended the workshop, where all steps for completing the annual form were explained in detail, along with practical guidelines to ensure accuracy and ease in providing the required information. This workshop was a great opportunity for exchanging experiences and raising questions and inquiries, contributing to the creation of an effective educational environment that enhances the level of information and interaction among participants.
The Head of the Department of Applied Sciences congratulates the faculty and staff of the department on the occasion of the university ranking first locally in the Times Higher Education ranking
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The Head of the Department of Applied Sciences congratulates the faculty and staff of the department on the occasion of the university ranking first locally in the Times Higher Education ranking
Professor Raed Abdul Wahab Ismail, Head of the Department of Applied Sciences, extended his congratulations to the faculty and staff of the department on the occasion of the university achieving first place locally in the 2025 Times Higher Education World University Rankings.
The results of the "THE World University Rankings 2025" were announced, where the University of Technology achieved a remarkable accomplishment by securing first place locally among Iraqi universities for the second consecutive year, out of a total of 18 universities ranked this year. Additionally, the University of Technology was ranked in the (1001 – 1200) category among 2,092 global universities included in the ranking.
The "World University Rankings" are based on a set of various academic criteria, including teaching, scientific research, and the international reputation of universities. This ranking is considered one of the most prestigious and reliable globally.
The Head of the Department urged the department's faculty to double their efforts in scientific research to enhance our beloved university's global ranking even further.
Biotechnology organized a workshop on 'The Use of the Professor System within the Bologna System Framework'
Written by alyaa
Biotechnology organized a workshop on 'The Use of the Professor System within the Bologna System Framework'
Biotechnology organized a workshop on 'The Use of the Professor System within the Bologna System Framework.
The Biotechnology Department organized a workshop on how to use the Professor System within the Bologna System framework. The lectures were delivered by Dr. Intisar Hussein Ali, Head of the Biotechnology Department, Dr. Maryam Dhari Kamel, Rapporteur of the Biotechnology Department, and Assistant Lecturer Bassam Shaker Mahmoud. The workshop covered several key topics, including:
Explaining the mechanism for creating a teacher account and how to add absences and record formative assessment grades.
Clarifying students' rights and responsibilities, in addition to the process of registering for academic courses.
After the workshop, the challenges faced by teachers in using the system were discussed, and quick and appropriate solutions were provided according to the guidelines and regulations. This discussion contributed to significant scientific benefits and improvements.
The Department of Applied Sciences Council awards the President of the University of Technology a certificate of appreciation
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The Department of Applied Sciences Council awards the President of the University of Technology a certificate of appreciation
The Presidency and the Council of the Department of Applied Sciences at the University of Technological , represented by the Head of the Department, Professor Dr. Raid Abd Al-Wahab Ismail, awarded a certificate of appreciation to the President of the University of Technology , Professor Dr. Ahmed Mohammed Hassan Al-Ghabban, in recognition and gratitude for his continuous support to the researchers, professors, faculty, and staff of the department and the university.
This initiative came during the President's attendance at the opening of some of the department's laboratories after their renovation.For his part, the President affirmed his continuous support for all the scientific and engineering departments of the university, as well as for its professors, faculty members, staff, and students, in a way that serves the educational process. He wished everyone continued success and prosperity in service of our beloved Iraq and our distinguished university.
The President of the University of Technology inaugurates the laboratories of the Biotechnology Department after their renovation
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The President of the University of Technology inaugurates the laboratories of the Biotechnology Department after their renovation
Professor Dr. Ahmed Mohammed Hassan Al-Ghaban, the President of the University, cut the ribbon to inaugurate the laboratories of the Biotechnology Department after the completion of their renovation. The renovation project received direct support from the Head of the Department of Applied Sciences, Professor Dr. Raid Abdulwahab Ismail, under the supervision of the Head of the Biotechnology Branch, Professor Dr. Intisar Hussein Ali.
The inauguration ceremony was attended by the Assistant President of the University for Administrative Affairs, Professor Dr. Farhad Mohammed Othman, along with the department’s administrative and scientific assistants and several faculty members from the Biotechnology Branch.
During the inauguration ceremony, The President of the University praised the efforts and exceptional contributions made by the faculty members of the department in general, and the Biotechnology Branch in particular, in completing this work in a short time. He also commended the department’s desire to establish a strategy that contributes to the development and renovation of the department’s laboratories, providing a suitable and ideal environment for our students
The Applied Chemistry Department organized a workshop on the use of the Bologna System.
Written by alyaa
The Applied Chemistry Department organized a workshop on the use of the Bologna System
The Applied Chemistry Department organized a workshop on "The Use of the Professor System within the Bologna Framework: Roles, Duties, and the Rights and Obligations of Students."
The lectures were delivered by Assistant Lecturer Jasim Muhammad Jalil, Director of the Registration Department in the Department of Oil and Gas Engineering; Professor Dr. Khalida Farhan Suhail, Head of the Applied Chemistry Department; and Lecturer Dr. Thamer Adnan Abdullah, Rapporteur of the Applied Chemistry Department. The main topics addressed included:
• An explanation of the mechanism for creating a Professor account and how to add absences and record formative assessment grades.
• Clarification of students' rights and obligations, in addition to the mechanism for registering academic courses.
At the end of the workshop, the scientific outcomes and challenges faced by the students were discussed. The dialogue was fruitful and contributed valuable scientific insights for the students.
The workshop was attended by department members and staff from the Applied Chemistry Department.
"The Head of the Applied Sciences Department Chaired the Master's Thesis Defense Committee for a student at Al-Anbar University."
Written by alyaa"Professor Dr. Raid Abdul Wahab Ismail, Head of the Applied Sciences Department, Chaired the Master's Thesis Defense Committee for a student at Al-Anbar University."
"Professor Dr. Raid Abdul Wahab Ismail, Head of the Applied Sciences Department, chaired the Master's Thesis Defense Committee for a student at Al-Anbar University.
The public defence for Master's student 'Ahmed Hamid Aboud' was held in the Physics Department, College of Science / Al-Anbar University, in the Ibn Sina Hall, discussing his thesis titled:
'Fabrication and Spectroscopic Analysis of Wide-Range Multilayer Nanostructured Optical Detectors Si / ZnTe / ZnO.'
Following the discussion and valuable comments from the committee members, the thesis was accepted."
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A graduate student from the Applied Physics Department earns a master's degree for the thesis titled "Preparation and Characteristics study of n-BaTiO3 /p-Si and n-BaTiO3/n-CdS/p-Si photodetectors by laser ablation"
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The Applied Physics Department awarded a master's degree to the graduate student "Nadheer Zaid Abdul Yaqoub."
The Applied Physics Department awarded a master's degree to the graduate student "Nadheer Zaid Abdul Yaqoub" for his thesis titled
“Preparation and Characteristics study of n-BaTiO3 /p-Si and n-BaTiO3/n-CdS/p-Si photodetectors by laser ablation
“
The discussion was held in the late Professor Ibrahim Al-Jawadi Hall in the building of lecture halls and laboratories in the department. The discussion committee consisted of:
- Professor Dr. Udai Mohsen Naif
- Department of Applied Sciences / Applied Physics Branch - Chair
- Assistant Professor Dr. Mohammed Salman Mohammed
- Department of Applied Sciences / Laser Science and Technology Branch - Member
- Assistant Professor Dr. Ammar Ayesh Habeeb
- University of Diyala / College of Science / Department of Physics - Member
- Professor Dr. Raed Abdul Wahab Ismail
- Department of Applied Sciences / Laser Science and Technology Branch - Member and Supervisor
- Assistant Professor Dr. Suad Salem Shaker
- Department of Applied Sciences / Applied Physics Branch - Member and Supervisor
In this work, nanostructured BaTiO3 films on silicon and glass have been produced by the pulsed laser deposition (PLD) method at different deposition conditions (different laser fluence (8.2to 10.1 J/cm2 ),different substrate temperatures(25 to150⁰C), and a tandem nanostructured n-BaTiO3/n-CdS/p-Si at a varied number of laser pulses(100-300puls). A homemade-pulsed laser utilizes a deposition (PLD) system comprising a Q-switched Nd: YAG laser operating at a wavelength of 532 nm (second harmonic) with a pulse duration of 7ns.Revealed the formation of crystalline nanostructured BaTiO3 with mixed tetragonal and hexagonal phases, with the 150°C deposit having the highest crystallinity and largest particle size. The BaTiO3thin films were created at different laser fluences (8.2 to 10.1 J/cm2) with a constant substrate temperature of 100°C. There was a noticeable increase in the grain size of the film with an increasing laser fluence. The grown films are polycrystalline and exhibit a combination of tetragonal and hexagonal phases, with the film's crystallinity improving as the laser fluence increases. The optical transmittance of the film decreases as the substrate temperature increases and decreases with an increase as the laser fluence increases. Photoluminescence (PL) studies show emission peaks at 477, 574, 561, and 380 nm for BaTiO3 films deposited at 8.2, 8.9, 9.5, and 10.1 J/cm2, respectively. The Hall coefficient of the films was negative, indicating that the films are n-type. The best performance was observed at a laser fluence of 8.9 J/cm2, with a sensitivity of 9.2 A/W at 500 nm and a detectivity of 4.62×1012Jones. A tandem nanostructured n-BaTiO3/p-CdS/p-Si was successfully fabricated, achieving an external quantum efficiency of 153% and a detectivity of 7.4×1012 Jones at 100 pulses.
A graduate student from the Department of Mathematics and Computer Applications obtains a master's degree for his thesis on "On the interaction indices of bi-cooperative games"
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The Department of Mathematics and Computer Applications awarded a master's degree to the graduate student "Mohammed Mousa Mohammed"
The Department of Mathematics and Computer Applications awarded a master's degree to the graduate student "Mohammed Mousa Mohammed" for his thesis titled...
“On the interaction indices of bi-cooperative games
“
The defence was held in the late Professor Dr. Mohammed Sardar Ismail Hall in the department building, and the examination committee was composed of...
- Professor Dr. Suha Najib Shehab
- Department of Applied Sciences / Mathematics and Computer Applications Branch Chair
- Professor Dr. Rana Fareed Ghani
- Technical University / Department of Computer Science Member
- Assistant Professor Dr. Haider Majid Abbas
- University of Baghdad / College of Science for Women / Department of Mathematics Member
- Professor Dr. Jabbar Abbas Ghafil
- Department of Applied Sciences / Mathematics and Computer Applications Branch Member and Supervisor
In this thesis, first we apply a mathematical model based on using the optimization problem's implementation as working procedure to modeling cooperation among power stations and fuel supply producers. Secondly, we use the cooperative game to show the potential cost in case of cooperation through an optimization algorithm to find the most feasible solution using Python program as working procedure. Consequently, based on the important and interaction indices-based optimization algorithm, we employ an application of the methodology to a study case for the fuel supply and electric power production in the Wassit thermal station to demonstrating cooperation benefits between power stations and fuel suppliers which fosters strategy formulation in electrical power management. Experts will greatly benefit from the outcomes of the suggested methodology's testing as they work to refine future electrical power management systems' organised techniques.
A graduate student from the Department of Biotechnology obtains a master's degree for her thesis on "Evaluation of some immunological markers in Helicobacter Pylori infection"
Written by ali
The Biotechnology Department awarded a master's degree to the graduate student "Dhefaf Raheem Rasan"
The Biotechnology Department awarded a master's degree to the graduate student "Dhefaf Raheem Rasan" for her thesis titled...
“Evaluation of some immunological markers in Helicobacter Pylori infection
“
The defence was held in the late Professor Ibrahim Al-Jawadi Hall in the building of classrooms and laboratories in the department, and the examination committee was composed of...
- Professor Dr. Ali Abdulrahman Taha
- Department of Applied Sciences / Biotechnology Branch Chair
- Assistant Professor Dr. Aseel Shaker Mahmoud
- University of Baghdad / College of Science Member
- Assistant Professor Dr. Suhad Adnan Ahmed
- Department of Applied Sciences / Biotechnology Branch Member
- Professor Dr. Majid Sukhi Jabir
- Department of Applied Sciences / Biotechnology Branch Member and Supervisor
This thesis presents an in-depth investigation into the physical properties of SnO2- based photoanode electrodes used in solar cells, prepared using various SnO2 concentrations. The study involves a comprehensive analysis of the structural, morphological, and chemical properties of the materials using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA). The results show that the crystallinity and lattice parameters of the materials are consistent across different SnO2 concentrations, while the particle size and surface characteristics vary with SnO2 concentration. The photoluminescence (PL) spectroscopy analysis reveals a decrease in intensity with higher SnO2 concentrations, indicating a weaker interaction between the dye and SnO2. The performance characteristics of the Dye-sensitized Solar Cells (DSSCs) are analyzed in terms of short-circuit current density (Jsc), open-circuit voltage (Voc), fill factor (FF), and efficiency (η). The results show that the cell with the highest SnO2 concentration exhibits the best efficiency. This study provides valuable insights into the physical and chemical properties of SnO2 nanoparticles and their potential applications in solar energy conversion. The experimental results constitute a comprehensive evaluation of the performance and characteristics of the photoanode electrodes in solar cells, contributing to the ongoing research in renewable energy technologies.
A graduate student from the Department of Applied Chemistry obtains a master's degree for her thesis on "Evaluation of Acetylated Peptide Antibodies and Some Biochemical Parameters in Patients with Rheumatoid Arthritis"
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The Department of Applied Chemistry awarded a master's degree to the graduate student "Fatima Qasim Hussein"
The Department of Applied Chemistry awarded a master's degree to the graduate student "Fatima Qasim Hussein" for her thesis titled...
“Evaluating Anti-Acetylated Peptide Antibodies and Some Biochemical Parameters in Serum of Patient with Rheumatoid Arthritis
“
he defense was held in the late Professor Dr. Abdul Muttalib Ibrahim Al-Sheikh Hall in the department building, and the examination committee consisted of...
- Professor Dr. Bushra Fares Hassan
- University of Baghdad / College of Science for Women Chair
- Assistant Professor Dr. Mohammed Shamil Ali
- Department of Applied Sciences / Applied Chemistry Branch Member
- Assistant Professor Dr. Wafaa Raji Mohammed
- Department of Applied Sciences / Applied Chemistry Branch Member
- Professor Dr. Abdul Nasser Mohammed Abdullah
- Department of Applied Sciences / Applied Chemistry Branch Member and Supervisor
- Professor Dr. Mohammed Hadi Munshid Al-Asami
- University of Baghdad / College of Medicine Member and Supervisor
One hundred ten RA patients (13. 63 % male, 86.36% female) with a mean age of 23.8±6.8 years and while forty were apparently healthy control individuals with no signs or history of any autoimmune diseases or malignancies were involved in this study that was conducted in the period between Sep.2022 to Jan. 2023. The Patients divided into three subgroup: (1) biological treatment subgroup (consisted of thirty -eight patients on the bDMARDs treatment), (2) conventional cDMARD subgroup [thirty - eight patients received Methotrexate (MTX)] and (3) combined DMARD subgroup (thirty –four patients had received biology and chemotherapy). The human anti citrullinated peptide antibodies (ACPAs), human anti acetylated peptide antibodies (AAPAs), human acetylated Lysine antibodies (AcLys), human anti acetylated ornithine antibodies (AcOrns) were determined by Enzyme Linked Immunosorbent Assay (ELISA) and Zinc, Copper, LDH and alkaline phosphatase levels were used to measure by spectrophotometer in the serum for RA patients and apparently healthy controls. The results reveal that a high significant increase in prevalence of ACPA in RA more than apparently healthy. There are three acelyted peptide antibodies (AAPA, AcLys and AcOrn) are highly prevalent in RA and occur also independently of RF and ACPA. Moreover, high significant decrease difference in the serum level of AcLys (P<0.001) in chemotherapy group in comparison to other subgroup as well as a significant decrease (p=0.0149 ) in the serum levels of AcOrn between Biology vs. Chemotherapy RA patients subgroups. Significant decrease in serum Zn levels in healthy control compared to the sub group of RA patients. A high significant increase in serum Cu levels in sub group of RA patients compared to the healthy control. Moreover, High significant level of LDH in RA compared to healthy control and high significant decrease LDH in biology subgroup compared to other treatment subgroup of RA. the positive correlation between ACPA with AAPA, AcLys and with dieses activity score 28 (DAS28). In conclusion, the evaluating of autoantiody (ACPA,AAPA,AcLys, AcOrn) in RA and multiple AAPA reactivity increased the specificity for RA, suggesting high diagnostic value of AAPA testing. Furthermore, Cu and LDH as a marker for inflammation in RA.
